Which of the following best describes a high tolerance to alcohol?

A high tolerance to alcohol refers to the body's adaptation to the substance, allowing an individual to consume larger quantities without experiencing the typical effects associated with alcohol consumption, such as impairment or intoxication. This adaptation occurs because repeated exposure to alcohol can lead to physiological changes in the brain and body, which diminishes the perceived effects of alcohol over time.

In contrast, the other options do not accurately describe this concept. For example, the notion of being unable to drink anymore describes a situation of overconsumption or physical incapacity, rather than tolerance. Similarly, referring to a temporary condition or knowledge of safe drinking limits does not address the physiological adaptation processes that characterize high tolerance. Thus, the correct answer captures the essence of high tolerance as the ability to drink more without feeling the normal effects of alcohol.